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Image Search Results
Journal: International Journal of Nanomedicine
Article Title: Thermosensitive in situ Hydrogel Based on Benzalkonium Chloride-Loaded Selenium-Doped Mesoporous Silica Nanoparticles for Diabetic Chronic Wound Treatment
doi: 10.2147/IJN.S594500
Figure Lengend Snippet: Biocompatibility, antioxidant, and anti-inflammatory effects of BAC@Se-MSNs/PF127 hydrogel in vitro. ( A and B ) CCK-8 assay showing viability of HUVECs ( A ) and NIH-3T3 cells ( B ) after 1, 3, and 5 days under different treatments (Control, PF127, BAC@Se-MSNs/PF127 at 0.5, 1.0, 2.0 mg/mL). ( C ) Live/Dead staining shows great cell viability (green) in all groups, exhibiting strong biocompatibility. ( D ) Cell survival after H 2 O 2 -induced oxidative damage, exhibiting considerable protection by BAC@Se-MSNs/PF127. ( E ) DPPH radical scavenging experiment revealing significant antioxidant activity of BAC@Se-MSNs/PF127. ( F ) Intracellular ROS levels demonstrating effective decrease by BAC@Se-MSNs/PF127. ( G – I ) RT-qPCR investigation revealing downregulation of pro-inflammatory factors IL-6 ( G ) and TNF-α ( H ) and overexpression of anti-inflammatory IL-10 ( I ) in BAC@Se-MSNs/PF127-treated cells. Data are shown as mean ± SD; *P < 0.05, ***P < 0.001, ****P < 0.0001, ns, not significant.
Article Snippet: HUVECs,
Techniques: In Vitro, CCK-8 Assay, Control, Staining, Antioxidant Activity Assay, Quantitative RT-PCR, Over Expression